The following guiding principles should be considered by any brand owner when introducing changes to an existing product and also when developing a GTIN assignment strategy for a new product.
At least one of the guiding principles must apply for a GTIN change to be required.

Is a consumer and/or trading partner expected to distinguish the changed or new product from previous/current products?

Is there a regulatory/liability disclosure requirement to the consumer and/or trading partner?

Is there a substantial impact to the supply chain (e.g., how the product is shipped, stored, received)?